Journal: Frontiers in Neurology

Article Title: Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis

doi: 10.3389/fneur.2022.858302

Figure Lengend Snippet: Laboratory parameters in patients from different stenosis subtypes.

Article Snippet: In brief, the serum was added to a microtiter plate that was pre-immobilized with a monoclonal antibody against Lp-PLA2 or hs-CRP (DPLG70, QK1707, R&D System, USA) and then incubated with anti-Lp-PLA2 or anti-hs-CRP antibody labeled with horseradish peroxidase.

Techniques:

Journal: Frontiers in Neurology

Article Title: Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis

doi: 10.3389/fneur.2022.858302

Figure Lengend Snippet: Serum lipoprotein-associated phospholipase A2 (Lp-PLA2) (A) and homocysteine (HCY) (B) levels in different stenosis subtypes. Lp-PLA2 levels were higher in the intracranial artery stenosis (ICAS) group than that in the other three groups, and the difference between the no cerebral artery stenosis (NCS) and ICAS groups was statistically significant (A) . The HCY level was significantly higher in the NCS group than in the intracranial and extracranial artery stenosis (IECS) group (B) .

Article Snippet: In brief, the serum was added to a microtiter plate that was pre-immobilized with a monoclonal antibody against Lp-PLA2 or hs-CRP (DPLG70, QK1707, R&D System, USA) and then incubated with anti-Lp-PLA2 or anti-hs-CRP antibody labeled with horseradish peroxidase.

Techniques:

Journal: Frontiers in Neurology

Article Title: Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis

doi: 10.3389/fneur.2022.858302

Figure Lengend Snippet: Percentage distribution of stenosis subtypes among the four quartiles of lipoprotein-associated phospholipase A2 (Lp-PLA2).

Article Snippet: In brief, the serum was added to a microtiter plate that was pre-immobilized with a monoclonal antibody against Lp-PLA2 or hs-CRP (DPLG70, QK1707, R&D System, USA) and then incubated with anti-Lp-PLA2 or anti-hs-CRP antibody labeled with horseradish peroxidase.

Techniques:

Journal: Frontiers in Neurology

Article Title: Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis

doi: 10.3389/fneur.2022.858302

Figure Lengend Snippet: Distribution of different stenosis subtypes in the third (A) and fourth (B) quartiles of Lp-PLA2. The prevalence of NCS, ICAS, extracranial artery stenosis (ECAS), and IECS according to the level of Lp-PLA2. There was a trend toward an increased risk of ICAS in the third and fourth quartile.

Article Snippet: In brief, the serum was added to a microtiter plate that was pre-immobilized with a monoclonal antibody against Lp-PLA2 or hs-CRP (DPLG70, QK1707, R&D System, USA) and then incubated with anti-Lp-PLA2 or anti-hs-CRP antibody labeled with horseradish peroxidase.

Techniques:

Journal: Frontiers in Neurology

Article Title: Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis

doi: 10.3389/fneur.2022.858302

Figure Lengend Snippet: Serum Lp-PLA2 levels and the severity of stenosis in ICAS. (A) Serum levels of Lp-PLA2 levels according to the number of ICAS. Compared with those with one lesion and with no arterial stenosis, Lp-PLA2 levels in patients with two or more lesions were higher. (B) Serum levels of Lp-PLA2 levels according to the severity of stenosis of ICAS. Lp-PLA2 levels in patients with severe ICAS were relatively higher than in those with moderate or mild ICAS. (C) Serum levels of Lp-PLA2 levels according to symptomatic and asymptomatic ICAS. There was no difference in the Lp-PLA2 level between patients with asymptomatic and symptomatic ICAS.

Article Snippet: In brief, the serum was added to a microtiter plate that was pre-immobilized with a monoclonal antibody against Lp-PLA2 or hs-CRP (DPLG70, QK1707, R&D System, USA) and then incubated with anti-Lp-PLA2 or anti-hs-CRP antibody labeled with horseradish peroxidase.

Techniques:

Journal: Journal of Neuroinflammation

Article Title: Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study

doi: 10.1186/s12974-022-02467-1

Figure Lengend Snippet: Associations of individual inflammation marker or combination of IL-6 and YKL-40 with recurrent stroke within 1 year

Article Snippet: The concentrations of IL-6, IL-1Ra, Lp-PLA 2 and YKL-40 were determined by using enzyme-linked immunosorbent assay kits (catalogue number: PHS600C for IL-6, PDRA00B for IL-1Ra, DPLG70 for Lp-PLA 2 and DC3L10 for YKL-40, R&D Systems, Inc, Minneapolis, MN, USA).

Techniques: Marker

Journal: Journal of Neuroinflammation

Article Title: Interleukin-6 and YKL-40 predicted recurrent stroke after ischemic stroke or TIA: analysis of 6 inflammation biomarkers in a prospective cohort study

doi: 10.1186/s12974-022-02467-1

Figure Lengend Snippet: Associations of individual inflammation marker or combination of IL-6 and YKL-40 with a Modified Rankin Scale score ≥ 2 within 1 year

Article Snippet: The concentrations of IL-6, IL-1Ra, Lp-PLA 2 and YKL-40 were determined by using enzyme-linked immunosorbent assay kits (catalogue number: PHS600C for IL-6, PDRA00B for IL-1Ra, DPLG70 for Lp-PLA 2 and DC3L10 for YKL-40, R&D Systems, Inc, Minneapolis, MN, USA).

Techniques: Marker, Modification